This is a really odd problem I've started having lately. On RSC routes or routes that I get through Steam, (Ohio Steel, Fort Kent) I can use the editors just fine. But on third party routes (NS AND, Willamete Pass), I can only use the scenario editor once. If I place any locomotives or rolling stock and save the changes, I can't go back into the world or scenario editors. If I try to, Railworks immediately crashes with a Something Bad Has Happened error.
The only way I can fix the problem is to completely remove the route and reinstall it but then the problem just happens all over again. Verifying my cache doesn't seem to help at all. Any ideas?