Several things to try for all of you. Most of us know all of this, but postrateofclimb may not (welcome, BTW

)
1) verify the game files. Open Steam, click on Libraries. Right click on Railworks> Properties> Local Files tab> Verify
2) On the game's opening screen, before you click START, go to tools and docks and clear the blueprint cache.
Now, this could also be a heat issue. If it's been a while since you "dusted" out your PC, it may be a good time to do so. Use canned air, never a vacuum. Video card could be getting hot causing the driver to fail, that will lock up Windows.
Could also be the game itself, but not likely. Could be the Steam client. I seem to have to reinstall Steam about every 3 months lately. Copy the "steamapps" folder to another place on the hard drive. Uninstall then reinstall Steam. Paste the "steamapps" folder back in and you are good to go. You may lose some modifications. I always save a copy of all third party "stuff" to a folder in Documents.
Ryzen 7 2700K, Asus Prime X570P, 32Gb DDR4, 2x 1Tb M.2 SSD's, RTX2060 6Gb, Occulus Rift
Win 10 Pro 64bit, keyboard/ mouse/ wheel/ pedals/ baseball bat
Security Coordinator on the Battleship Iowa